The domain within your query sequence starts at position 44 and ends at position 192; the E-value for the MREG domain shown below is 5.2e-74.
LERDDEKNLWSMPHDVSHTEADDDRILYNLIVIRNQQTKDSEEWQRLNYDIYTLRQIRRE VRNRWRRILEDLGFQREADSLLSVTKLSTMSDSKNTRKAREMLLKLAEETSIFPASWELS ERYLLVVDRLIALDAAEDFFKIASQMYPK
MREG |
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PFAM accession number: | PF15812 |
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Interpro abstract (IPR031638): | Melanoregulin (MREG) is a putative membrane fusion regulator that forms a complex with peripherin-2 [ (PUBMED:17260955) ]. It is required for lysosome maturation and plays a role in intracellular trafficking [ (PUBMED:19240024) ]. Melanoregulin is involved in the retrograde melanosome transport in melanocytes, which is dependent on the dynein-dynactin motor complex [ (PUBMED:22275436) ], and is a negative regulator of melanosome intercellular transfer [ (PUBMED:22753477) ]. Palmitoylation serves to stably anchor melanoregulin in the melanosome membrane [ (PUBMED:22940130) ]. |
GO process: | melanosome transport (GO:0032402) |
GO component: | melanosome (GO:0042470) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry MREG