The domain within your query sequence starts at position 86 and ends at position 229; the E-value for the Na_Ca_ex domain shown below is 2.4e-31.
HILGALYMFYALAIVCDDFFVPSLEKICEKLHLSEDVAGATFMAAGSSTPELFASVIGVF ITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTLSVIVLIAFIY DEEIVWWEGLVLIILYVFYILIMK
Na_Ca_ex |
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PFAM accession number: | PF01699 |
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Interpro abstract (IPR004837): | The sodium/calcium exchangers are a family of integral membrane proteins. This domain covers the integral membrane regions of these proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells [ (PUBMED:1700476) ]. Ca2+ is moved into or out of the cytosol depending on Na+ concentration [ (PUBMED:1700476) ]. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3 [ (PUBMED:8798769) ]. |
GO process: | transmembrane transport (GO:0055085) |
GO component: | integral component of membrane (GO:0016021) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry Na_Ca_ex