The domain within your query sequence starts at position 217 and ends at position 411; the E-value for the Nicastrin domain shown below is 2.1e-9.

PTIVIVAHYDAFGVAPWLSLGADSNGSGISVLLELARLFSRLYTYKRTHAAYNLLFFASG
GGKFNYQGTKRWLEDSLDHTDSSLLQDNVAFVLCLDTVGRGSHLRLHVSKPPREGTLQHA
FLRELETVAAHQFPDVSFSMVHKKINLADDVLAWEHERFAIRRLPAFTLSHLESHRAGPR
SSIMDVRSRVDSKTL

Nicastrin

Nicastrin
PFAM accession number:

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Nicastrin