The domain within your query sequence starts at position 273 and ends at position 498; the E-value for the Nicastrin domain shown below is 1.6e-94.

RVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALHKAPDVTTLSRNVMFVFFQGE
TFDYIGSSRMVYDMENGKFPVRLENIDSFVELGQVALRTSLDLWMHTDPMSQKNESVKNQ
VEDLLATLEKSGAGVPEVVLRRLAQSQALPPSSLQRFLRARNISGVVLADHSGSFHNRYY
QSIYDTAENINVTYPEWQSPEEDLNFVTDTAKALANVATVLARALY

Nicastrin

PFAM accession number:

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Nicastrin