The domain within your query sequence starts at position 3 and ends at position 53; the E-value for the Nop10p domain shown below is 3.1e-26.



PFAM accession number:PF04135
Interpro abstract (IPR007264):

In eukaryotes Nop10 is a nucleolar protein that is specifically associated with H/ACA snoRNAs. It is essential for normal 18S rRNA production and rRNA pseudouridylation by the ribonucleoprotein particles containing H/ACA snoRNAs (H/ACA snoRNPs). Nop10 is probably necessary for the stability of these RNPs [ (PUBMED:9843512) ].

H/ACA ribonucleoprotein particles (RNPs) are a family of RNA pseudouridine synthases that specify modification sites through guide RNAs. The function of these H/ACA RNPs is essential for biogenesis of the ribosome, splicing of precursor mRNAs (pre-mRNAs), maintenance of telomeres and probably for additional cellular processes [ (PUBMED:16647858) ]. All H/ACA RNPs contain a specific RNA component (snoRNA or scaRNA) and at least four proteins common to all such particles: Cbf5, Gar1, Nhp2 and Nop10. These proteins are highly conserved from yeast to mammals and homologues are also present in archaea [ (PUBMED:10871366) ]. The H/ACA protein complex contains a stable core composed of Cbf5 and Nop10, to which Gar1 and Nhp2 subsequently bind [ (PUBMED:19917616) ].

GO process:pseudouridine synthesis (GO:0001522), ribosome biogenesis (GO:0042254)
GO function:snoRNA binding (GO:0030515)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Nop10p