SMART: Pfam domain Orai-1

The domain within your query sequence starts at position 42 and ends at position 94; the E-value for the Orai-1 domain shown below is 1.3e-16.

SQHSLRALSWRRLYLSRAKLKASSRTSALLSGFAMQWPREVELKIPECGLQMC

Orai-1

PFAM accession number:	PF07856
Interpro abstract (IPR012446):	This entry includes Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 green fluorescent protein (GFP) reporters are co-expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1-related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins [ (PUBMED:17218360) ].

PFAM accession number:

PF07856

Interpro abstract (IPR012446):

This entry includes Drosophila Orai and human Orai1, Orai2 and Orai3. ORAI-1 green fluorescent protein (GFP) reporters are co-expressed with STIM-1 (ER CA(2+) sensors) in the gonad and intestine. The protein has four predicted transmembrane domains with a highly conserved region between TM2 ad TM3. This conserved domain is thought to function in channel regulation. ORAI1-related proteins are required for the production of the calcium channel, CRAC, along with STIM1-related proteins [ (PUBMED:17218360) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Orai-1