SMART: Pfam domain P66

The domain within your query sequence starts at position 158 and ends at position 201; the E-value for the P66_CC domain shown below is 1.7e-21.

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P66_CC

PFAM accession number:	PF16563
Interpro abstract (IPR032346):	This entry represents a short coiled-coil interaction region found in the transcriptional repressors P66alpha and P66beta. P66alpha and P66beta form complex with MBDs (methyl-binding domain-containing proteins) via a coiled-coil region on each. The MBD2-NuRD complex recognizes methylated DNA and silences expression of associated genes through histone deacetylase and nucleosome remodeling functions [ (PUBMED:21490301) (PUBMED:23239876) ].

PFAM accession number:

PF16563

Interpro abstract (IPR032346):

This entry represents a short coiled-coil interaction region found in the transcriptional repressors P66alpha and P66beta. P66alpha and P66beta form complex with MBDs (methyl-binding domain-containing proteins) via a coiled-coil region on each. The MBD2-NuRD complex recognizes methylated DNA and silences expression of associated genes through histone deacetylase and nucleosome remodeling functions [ (PUBMED:21490301) (PUBMED:23239876) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry P66_CC