The domain within your query sequence starts at position 37 and ends at position 177; the E-value for the PRA1 domain shown below is 3.2e-41.



PFAM accession number:PF03208
Interpro abstract (IPR004895):

Prenylated Rab acceptor protein 1 (PRA1) family includes PRAF1/2/3 from mammals,Yip3 from budding yeasts and several RPA proteins from plants.

In budding yeast, Yip3 interacts with members of the Rab GTPase family and may be involved in transport between the ER and Golgi complex [ (PUBMED:11157978) ].

In humans, PRAF1 is a general Rab protein regulator required for vesicle formation from the Golgi complex. It may control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes [ (PUBMED:12107180) ]. It inhibits the removal of Rab GTPases from the membrane by GDI [ (PUBMED:10751420) ]. PRAF2 plays a pro-apoptic role in cerulenin-induced neuroblastoma apoptosis [ (PUBMED:17975142) ]. PRAF3 negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate [ (PUBMED:12119102) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry PRA1