The domain within your query sequence starts at position 308 and ends at position 521; the E-value for the PRP3 domain shown below is 1.3e-82.

NTFFDPRVSIAPSQRQRRTFKFHDKGKFEKIAQRLRTKAQLEKLQAEISQAARKTGIHTS
TRLALIAPKKELKEGDIPEIEWWDSYIIPNGFDLTEENPKREDYFGITNLVEHPAQLNPP
VDNDTPVTLGVYLTKKEQKKLRRQTRREAQKELQEKVRLGLTPPPEPKVRISNLMRVLGT
EAVQDPTKVEAHVRAQMAKRQKAHEEANAARKLT

PRP3

PRP3
PFAM accession number:PF08572
Interpro abstract (IPR013881):

Pre-mRNA processing factor 3 (PRP3) is a U4/U6-associated splicing factor. The human PRP3 has been implicated in autosomal retinitis pigmentosa [ (PUBMED:11773002) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry PRP3