The domain within your query sequence starts at position 131 and ends at position 260; the E-value for the PS_Dcarbxylase domain shown below is 3.9e-35.
LSEFFRRKLKPQARPVCGLHCVTSPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGPRAN TEDLPFPPASSSDSFRNQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTISHRRHFPGPA HKQPQVQQGL
PS_Dcarbxylase |
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PFAM accession number: | PF02666 |
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Interpro abstract (IPR003817): | Phosphatidylserine decarboxylase plays a pivotal role in the synthesis of phospholipid by the mitochondria. The substrate phosphatidylserine is synthesized extramitochondrially and must be translocated to the mitochondria prior to decarboxylation [ (PUBMED:8407984) ]. Phosphatidylserine decarboxylases EC 4.1.1.65 is responsible for conversion of phosphatidylserine to phosphatidylethanolamine and plays a central role in the biosynthesis of aminophospholipids [ (PUBMED:7890740) ]. This family also includes L-tryptophan decarboxylase from the mushroom Psilocybe cubensis, which is required for the biosynthesis of the psychotropic agent psilocybin. This enzyme catalyses the first step in the biosynthetic pathway, converting L-tryptophan to tryptamine [ (PUBMED:28763571) ]. |
GO process: | phospholipid biosynthetic process (GO:0008654) |
GO function: | phosphatidylserine decarboxylase activity (GO:0004609) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry PS_Dcarbxylase