The domain within your query sequence starts at position 1 and ends at position 334; the E-value for the Pannexin_like domain shown below is 2.9e-133.

MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKV
EFDNQCAVPWDLLKGSENASSNSGLLLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKF
FPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVSILHKCFDSPWTTRALSETVAEQSVRP
LKLSKSKTLLSTSGGSADIDASKQSLPYPQPGLESPGIESPTSSVLDKKEGEQAKAIFEK
VKRFRLHVEQRDIIYRVYLKQIIVKVILFVLIITYVPYFLSYITLEIDCSIDVQAFTGYK
RYQCVYSLAEIFKVLASFYVILVMLYGLTSSYSL

Pannexin_like

 Pannexin_like
PFAM accession number:PF12534
Interpro abstract (IPR021040):

This entry represents the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space [ (PUBMED:22532330) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Pannexin_like