SMART: Pfam domain Plexin

The domain within your query sequence starts at position 1546 and ends at position 2086; the E-value for the Plexin_cytopl domain shown below is 6.5e-230.

GIPFLDYKVYAERVFFPGYRESPLHRDLGVPDSRRPTVEQGLGQLSNLLNSKLFLTKFIH
TLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTET
VVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVDSVTGKAKYTLNDNRLLR
EDVEYRPLTLNALLAVGPGAGEAQCVPVKVLDCDTISQAKEKMLDQLYKGVPLAQRPDSC
TLDVEWRSGVAGHLILSDEDVTSELQGLWRRLNTLQHYKVPDGATVALVPCLTKHILREN
QDYVPGERTPMLEDVDEGGIRPWHLVKPSDEPEPPRPRRGSLRGGERERAKAIPEIYLTR
LLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNSL
PLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYARD
IPRYKQMVERYYADIRQTVPASDQEMNSVLAELSRNCSADLGARVALHELYKYINKYYDQ
I

Plexin_cytopl

PFAM accession number:	PF08337
Interpro abstract (IPR013548):	This domain is found at C terminus of various plexins (e.g. P51805 ). Plexins are receptors for semaphorins, and plexin signalling is important in pathfinding and patterning of both neurons and developing blood vessels [ (PUBMED:15239959) (PUBMED:11959816) ]. The cytoplasmic region, which has been called a SEX domain [ (PUBMED:8570614) ], and is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins [ (PUBMED:12559962) ].

PFAM accession number:

PF08337

Interpro abstract (IPR013548):

This domain is found at C terminus of various plexins (e.g. P51805 ). Plexins are receptors for semaphorins, and plexin signalling is important in pathfinding and patterning of both neurons and developing blood vessels [ (PUBMED:15239959) (PUBMED:11959816) ]. The cytoplasmic region, which has been called a SEX domain [ (PUBMED:8570614) ], and is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins [ (PUBMED:12559962) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Plexin_cytopl