SMART: Pfam domain SGT1

The domain within your query sequence starts at position 14 and ends at position 597; the E-value for the SGT1 domain shown below is 4.4e-247.

VEYHLFLIPDKARGTEEHREILQKYIERIMTQFAPILVPYIWQNQPFNLKYKPAKGGVPA
HMYGMTKFGDNIEDEWFIVYVIKQITKEFPELVARVEDNDGEFLLIEAADFLPKWLDPDN
SANRVFFHHGELCIIPVPRKSERIPWLPMTPPTIQQALSIISAHPEAVLASESIQAAVDR
RVSGYPERVEASLHRAHCFLPAGIVAVLKQQPRLLSAAVQAFYLRDPIDLRACRVFKTFL
PETRIMASVTFTKCLYAQLVQQKFVPDRRSGYGLPPPSHPQYRAYELGMKLAHGFEILCS
KCSPHFSDSRKSLVTASPLWASFLESLKRNDYFKGLMDGSAQYQERLEMAKNYFQLSIHR
PESSLAMSPGEEILTVLQTQPFDVAELKTEEADLPPEDDDQWLDLSPDQLDQLLQDAAGR
KESQPGPQKEELQNYDVAQVSDSMKAFISKVSSHKGAELPRDPSEAPITFDADSFLNYFD
KILGAKPQESDSEDDPGEEDVEGVDSDDDVGFEAQESESLKGALGSLKSYMARMDQELAH
TSMGRSFTTRERLNKDPPSHTANDNSDEEDSGAGDCAVEAVDVD

SGT1

PFAM accession number:	PF07093
Interpro abstract (IPR010770):	This entry represents Ecd (ecdysoneless) family. Drosophila ecd mutants display reduced steroid titers during larval development [ (PUBMED:16592466) ]. Mammalian Ecd (also known as SGT1 and hEcd in humans) has been shown to stimulate cell proliferation by interacting with the Retinoblastoma (Rb) proteins [ (PUBMED:19640839) ]. Ecd proteins may be involved in pre-mRNA splicing [ (PUBMED:24722212) ]. Overexpression of Ecd has been linked to cancer progression [ (PUBMED:22270930) (PUBMED:22977192) ].

PFAM accession number:

PF07093

Interpro abstract (IPR010770):

This entry represents Ecd (ecdysoneless) family. Drosophila ecd mutants display reduced steroid titers during larval development [ (PUBMED:16592466) ]. Mammalian Ecd (also known as SGT1 and hEcd in humans) has been shown to stimulate cell proliferation by interacting with the Retinoblastoma (Rb) proteins [ (PUBMED:19640839) ]. Ecd proteins may be involved in pre-mRNA splicing [ (PUBMED:24722212) ].

Overexpression of Ecd has been linked to cancer progression [ (PUBMED:22270930) (PUBMED:22977192) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry SGT1