SMART: Pfam domain SPAR

The domain within your query sequence starts at position 1483 and ends at position 1727; the E-value for the SPAR_C domain shown below is 4.4e-86.

KRHQSDGNEIAHTRLRASTRDLQASPKPTSKSTIEEDLKKLIDLESPTPESQKNFKFHAL
SSPQSPFPTTPTSRRALHRTLSDESIYSSQREHFFTSRASLLDQALPNDVLFSSTYPSLP
KSLPLRRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPIPDPGLMPLPDAASDLDWSNLV
DAAKAYEVQRASFFAASDENHRPLSAASNSDQLEEQALVQMKSYSSKDPSPTLASKVDQL
EGMLK

SPAR_C

PFAM accession number:	PF11881
Interpro abstract (IPR021818):	This domain is found in C-terminal of the signal-induced proliferation-associated 1-like (SIPA1L) proteins, including SIPA1L 1-3 from humans. SIPA1Ls shares protein sequence similarity with signal-induced proliferation-associated protein 1 (SIPA1), which is a GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 [ (PUBMED:9346962) (PUBMED:15310461) ]. In rats SIPA1L1 (also known as SPAR) has been identified as a Rap-specific GTPase-activating protein [ (PUBMED:11502259) ].

PFAM accession number:

PF11881

Interpro abstract (IPR021818):

This domain is found in C-terminal of the signal-induced proliferation-associated 1-like (SIPA1L) proteins, including SIPA1L 1-3 from humans. SIPA1Ls shares protein sequence similarity with signal-induced proliferation-associated protein 1 (SIPA1), which is a GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 [ (PUBMED:9346962) (PUBMED:15310461) ]. In rats SIPA1L1 (also known as SPAR) has been identified as a Rap-specific GTPase-activating protein [ (PUBMED:11502259) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry SPAR_C