The domain within your query sequence starts at position 73 and ends at position 290; the E-value for the SURF1 domain shown below is 5.9e-64.







SURF1

SURF1




PFAM accession number:PF02104

Interpro abstract (IPR002994):
    
        This entry includes SURF1 and Shy1 proteins. The surfeit locus 1 gene (SURF1 or surf-1) encodes a  conserved protein of about 300 amino-acid residues that  seems  to be involved in the biogenesis of cytochrome c oxidase [       (PUBMED:9843204)       ].  Vertebrate SURF1  is  evolutionary related to yeast protein Shy1, which is a mitochondrial inner membrane protein required for assembly of cytochrome c oxidase [       (PUBMED:11782424)       ].  There  seems to be two transmembrane regions in these proteins, one in the N-terminal, the other in the C-terminal.     
            
       Defects in SURF1 are a cause of Leigh syndrome (LS). LS is a severe neurological disorder characterised by bilaterally symmetrical necrotic lesions in subcortical brain regions that is commonly associated with systemic cytochrome c oxidase (COX) deficiency [       (PUBMED:9843204)              (PUBMED:10746561)              (PUBMED:10647889)       ].      
 



GO component:membrane (GO:0016020)




This is a PFAM domain. For full annotation and more information, please see the PFAM entry SURF1