The domain within your query sequence starts at position 135 and ends at position 342; the E-value for the SURF6 domain shown below is 1e-45.
LSAATLEKRQRRKQERERKKRKRKERQAKQQVAEAEKKEEPVEVTPKMACKELQESGLIF NKVEVTEEEPASKAQRKKEKRQKVKGNLTPLTGRNYRQLLDRLQARQGRLDELRDQDAAK AQELEAKMKWTNLLYKAEGVKIRDDERLLQEALKRKEKRRAQRQRKWEKRSEHVVEKMQQ RQDKRRQNLRKKKAARAERRLQKAHKKG
SURF6 |
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PFAM accession number: | PF04935 |
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Interpro abstract (IPR029190): | This entry represents the C-terminal domain of the ribosomal RNA-processing protein 14 (Rrp14), which shares protein sequence similarity with surfeit locus protein 6 (SURF6). In mammals, SURF6 is a component of the nucleolar matrix and has a strong binding capacity for nucleic acids [ (PUBMED:9548374) ]. SURF6 is always found in the nucleolus regardless of the phase of the cell cycle suggesting that it is a structural protein constitutively present in nucleolar substructures. A role in rRNA processing has been proposed for this protein. Saccharomyces cerevisiae member of the SURF-6 family, named Rrp14 (ribosomal RNA-processing protein 14), interacts with proteins involved in ribosomal biogenesis and cell polarity [ (PUBMED:15629442) ]. It is required for the synthesis of both 40S and 60S ribosomal subunits and may also play some direct role in correct positioning of the mitotic spindle during mitosis [ (PUBMED:17272295) (PUBMED:17804645) ]. |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry SURF6