The domain within your query sequence starts at position 463 and ends at position 486; the E-value for the Shugoshin_C domain shown below is 2.2e-11.

LTKRRCSTIKSYKEPTLASKLRRG

Shugoshin_C

Shugoshin_C
PFAM accession number:PF07557
Interpro abstract (IPR011515):

This entry represents the C-terminal domain of Shugoshin (Sgo1) kinetochore-attachment proteins. Shugoshin has a conserved coiled-coil N-terminal domain and a highly conserved C-terminal basic region ( IPR011516 ). Shugoshin is a crucial target of Bub1 kinase that plays a central role in chromosome cohesion during mitosis and meiosis divisions by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms [ (PUBMED:14730319) (PUBMED:18987869) ]. Shugoshin is thought to act by protecting Rec8 and Rad21 at the centromeres from separase degradation during anaphase I (during meiosis) so that sister chromatids remain tethered [ (PUBMED:14730319) ]. Shugoshin also acts as a spindle checkpoint component required for sensing tension between sister chromatids during mitosis, its degradation when they separate preventing cell cycle arrest and chromosome loss in anaphase, a time when sister chromatids are no longer under tension. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly [ (PUBMED:16687935) ]. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process [ (PUBMED:17322402) ].

GO process:meiotic chromosome segregation (GO:0045132)
GO component:chromosome, centromeric region (GO:0000775), nucleus (GO:0005634)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Shugoshin_C