The domain within your query sequence starts at position 208 and ends at position 361; the E-value for the Steroid_dh domain shown below is 3.8e-22.
GHSPMKNLIKGCAFYWGFTSWMAYYINHPRYTPPSFGNRQVIVSAINFLFCEAGNHFINT VLAHPNHTGSNACFPSPNYNPFTWLFFLVSCPNYTYEIGSWISFTVMTQTLPVGIFTILM TIQMSLWARKKHKIYRKKFNSYVHRKSAIIPLIL
Steroid_dh |
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PFAM accession number: | PF02544 |
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Interpro abstract (IPR001104): | 3-oxo-5-alpha-steroid 4-dehydrogenases, EC 1.3.99.5 catalyse the conversion of 3-oxo-5-alpha-steroid + acceptor to 3-oxo-delta(4)-steroid + reduced acceptor. The steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during foetal development [ (PUBMED:1686016) ]. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related steroid reductase enzyme, DET2, is found in plants such as Arabidopsis. Mutations in this enzyme cause defects in light-regulated development [ (PUBMED:8602526) ]. This domain is present in both type 1 and type 2 [ (PUBMED:1944596) ] forms. This domain is also found in polyprenol reductase (SRD5A3; EC 1.3.1.94 ), which is reduces the alpha-isoprene unit of polyprenol to form dolichol. Dolichol is required for the synthesis of a dolichol-linked monosaccharide and the oligosaccharide precursor used for N-glycosylation [ (PUBMED:20637498) ]. Another enzyme with this domain is very-long-chain enoyl-CoA reductase (TECR; EC 1.3.1.93 ), which catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle by reducing the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation [ (PUBMED:12482854) ]. |
GO process: | lipid metabolic process (GO:0006629) |
GO function: | oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry Steroid_dh