The domain within your query sequence starts at position 1 and ends at position 133; the E-value for the Synaphin domain shown below is 3.1e-45.



PFAM accession number:PF05835
Interpro abstract (IPR008849):

This family consists of several eukaryotic synaphin 1 and 2 proteins. Synaphin/complexin is a cytosolic protein that preferentially binds to syntaxin within the SNARE complex. Synaphin promotes SNAREs to form precomplexes that oligomerise into higher order structures. A peptide from the central, syntaxin binding domain of synaphin competitively inhibits these two proteins from interacting and prevents SNARE complexes from oligomerising. It is thought that oligomerisation of SNARE complexes into a higher order structure creates a SNARE scaffold for efficient, regulated fusion of synaptic vesicles [ (PUBMED:11239399) ]. Synaphin promotes neuronal exocytosis by promoting interaction between the complementary syntaxin and synaptobrevin transmembrane regions that reside in opposing membranes prior to fusion [ (PUBMED:12200427) ].

GO process:neurotransmitter transport (GO:0006836)
GO function:syntaxin binding (GO:0019905)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Synaphin