The domain within your query sequence starts at position 39 and ends at position 276; the E-value for the TGFb_propeptide domain shown below is 3.7e-55.



PFAM accession number:PF00688
Interpro abstract (IPR001111):

TGF-beta is secreted as a latent complex, consisting of the TGF-beta dimer non-covalently bound to LAP (latency associated peptide) plus a latent TGF-beta binding protein (LTBP). After post-translational processing, TGF-beta binds non-covalently to LAP, a homodimer formed from the propeptide region of TGF-beta, to confer latency [ (PUBMED:9150447) ]. Latent TGF-beta can then be targeted to the extracellular matrix (ECM) by LTBP. The LAP dimer is usually disulfide-bound to LTBP [ (PUBMED:15611103) ].

This entry represents the propeptide region of TGF-beta that forms LAP.

This is a PFAM domain. For full annotation and more information, please see the PFAM entry TGFb_propeptide