The domain within your query sequence starts at position 1 and ends at position 241; the E-value for the TP_methylase domain shown below is 1.6e-23.



PFAM accession number:PF00590
Interpro abstract (IPR000878):

Tetrapyrroles are large macrocyclic compounds derived from a common biosynthetic pathway [ (PUBMED:11215515) ]. The end-product, uroporphyrinogen III, is used to synthesise a number of important molecules, including cobalamin (vitamin B12), haem, sirohaem, chlorophyll, coenzyme F430 and phytochromobilin [ (PUBMED:17227226) ].

These enzymes catalyse the methylation of their substrates using S-adenosyl-L-methionine as a methyl source. Enzymes in this family include:

  • Uroporphyrinogen III methyltransferase ( EC ) (SUMT), which catalyses the conversion of uroporphyrinogen III to precorrin-2 at the first branch-point of the tetrapyrrole synthesis pathway, directing the pathway towards cobalamin or sirohaem synthesis [ (PUBMED:15522295) ].
  • Precorrin-2 C20-methyltransferase CobI/CbiL ( EC ), which introduces a methyl group at C-20 on precorrin-2 to produce precorrin-3A during cobalamin biosynthesis. This reaction is key to the conversion of a porphyrin-type tetrapyrrole ring to a corrin ring [ (PUBMED:17229157) ]. In some species, this enzyme is part of a bifunctional protein.
  • Precorrin-4 C11-methyltransferase CobM/CbiF ( EC ), which introduces a methyl group at C-11 on precorrin-4 to produce precorrin-5 during cobalamin biosynthesis [ (PUBMED:16866557) ].
  • Sirohaem synthase CysG ( EC ), domains 4 and 5, which synthesizes sirohaem from uroporphyrinogen III, at the first branch-point in the tetrapyrrole biosynthetic pathway, directing the pathway towards sirohaem synthesis [ (PUBMED:14595395) ].
  • Diphthine synthase ( EC ), which carries out the methylation step during the modification of a specific histidine residue of elongation factor 2 (EF-2) during diphthine synthesis.

This entry represents a tetrapyrrole methylase domain, which consist of two non-similar subdomains [ (PUBMED:15522295) ].

GO function:methyltransferase activity (GO:0008168)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry TP_methylase