SMART: Pfam domain Titin

The domain within your query sequence starts at position 645 and ends at position 686; the E-value for the Titin_Z domain shown below is 1.3e-10.

QEKKRKEVETTALSTIAVATAKAKEQETVLRSREAMATRQEH

Titin_Z

PFAM accession number:	PF09042
Interpro abstract (IPR015129):	This entry represents the Z-repeat (approximately 45 amino acid sequences) found in the N terminus of titin [ (PUBMED:10819994) ]. The Z-repeat recognises and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34). It adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34. This interaction is essential for sarcomere assembly [ (PUBMED:11573089) ].

PFAM accession number:

PF09042

Interpro abstract (IPR015129):

This entry represents the Z-repeat (approximately 45 amino acid sequences) found in the N terminus of titin [ (PUBMED:10819994) ]. The Z-repeat recognises and binds to the C-terminal calmodulin-like domain of alpha-actinin-2 (Act-EF34). It adopts a helical structure, and binds in a groove formed by the two planes between the helix pairs of Act-EF34. This interaction is essential for sarcomere assembly [ (PUBMED:11573089) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Titin_Z