The domain within your query sequence starts at position 166 and ends at position 583; the E-value for the Tyr-DNA_phospho domain shown below is 2.4e-142.
QFYLTRVSGIKAKYNSKALHIKDILSPLFGTLVSSAQFNYCFDVDWLIKQYPPEFRKNPI LLVHGDKREAKADLHAQAKPYANISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNL IREDWHQKTQGIWLSPLYPRIDQGSHTAGESSTRFKADLTSYLTAYNAPPLQEWIDIIQE HDLSETNVYLIGSTPGRFQGSHRDNWGHFRLRKLLQAHAPSTPKGECWPIVGQFSSIGSL GPDESKWLCSEFKDSLLALREEGRPPGKSAVPLHLIYPSVENVRTSLEGYPAGGSLPYSI QTAEKQRWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKLAWFLVTSANLSKAAWGA LEKNGTQLMIRSYELGVLFLPSAFGLDTFKVKQKFFSSSCEPTASFPVPYDLPPELYG
Tyr-DNA_phospho |
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PFAM accession number: | PF06087 |
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Interpro abstract (IPR010347): | Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate [ (PUBMED:12023295) (PUBMED:19505854) ]. Mutations in human TDP1 gene cause spinocerebellar ataxia, autosomal recessive, with axonal neuropathy (SCAN1), which is a clinically and genetically heterogeneous group of cerebellar disorders [ (PUBMED:16141202) ]. |
GO process: | DNA repair (GO:0006281) |
GO component: | nucleus (GO:0005634) |
GO function: | phosphoric diester hydrolase activity (GO:0008081) |
This is a PFAM domain. For full annotation and more information, please see the PFAM entry Tyr-DNA_phospho