The domain within your query sequence starts at position 6 and ends at position 184; the E-value for the Uroplakin_II domain shown below is 6.2e-113.

PVQTLPLILILLAVLAPGTADFNISSLSGLLSPALTESLLIALPPCHLTGGNATLMVRRA
NDSKVVKSDFVVPPCRGRRELVSVVDSGSGYTVTRLSAYQVTNLTPGTKYYISYRVQKGT
STESSPETPMSTLPRKNMESIGLGMARTGGMVVITVLLSVAMFLLVVGLIVALALGARK

Uroplakin_II

Uroplakin_II
PFAM accession number:PF07353
Interpro abstract (IPR009952):

This family contains Uroplakin-2, which is approximately 180 residues long and seems to be restricted to mammals. Uroplakin II is an integral membrane protein, and is one of the components of the apical plaques of mammalian urothelium formed by the asymmetric unit membrane - this is believed to play a role in strengthening the urothelial apical surface to prevent the cells from rupturing during bladder distension [ (PUBMED:8175808) ].

Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet [ (PUBMED:27729990) (PUBMED:17183244) ]. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains separating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier [ (PUBMED:7760330) ]. Uroplakins are also believed to play a role during urinary tract morphogenesis [ (PUBMED:19340092) (PUBMED:17183244) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry Uroplakin_II