The domain within your query sequence starts at position 592 and ends at position 640; the E-value for the WHIM1 domain shown below is 1.8e-8.



PFAM accession number:PF15612
Interpro abstract (IPR028942):

WHIM1 is a conserved alpha helical motif that along with the WHIM2 and WHIM3 motifs, and the DDT domain comprise an alpha helical module found in diverse eukaryotic chromatin proteins [ (PUBMED:22186017) ].Based on the Ioc3 structure, this module is inferred to interact with nucleosomal linker DNA and the SLIDE domain of ISWI proteins [ (PUBMED:22186017) (PUBMED:21525927) ]. The resulting complex forms a protein ruler that measures out the spacing between two adjacent nucleosomes [ (PUBMED:21525927) ]. The conserved basic residue in WHIM1 is involved in packing with the DDT motif. The module shows a great domain architectural diversity and is often combined with other modified histone peptide recognizing and DNA binding domains, some of which discriminate methylated DNA [ (PUBMED:22186017) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry WHIM1