The domain within your query sequence starts at position 111 and ends at position 513; the E-value for the XK-related domain shown below is 2.6e-128.



PFAM accession number:PF09815
Interpro abstract (IPR018629):

This family is represented by the multipass membrane protein XK, which may be involved in sodium-dependent transport of neutral amino acids or oligopeptides. It forms a heterodimer with Kell. In humans, Kell is an 93kDa type II membrane glycoprotein with endothelin-3-converting enzyme activity that is linked by a single disulphide bond to XK, that spans the membrane ten times. An absence of XK leads to clinical symptoms termed the McLeod syndrome an X-linked multi-system disorder characterised by late onset abnormalities in the neuromuscular and hematopoietic systems [ (PUBMED:8004674) (PUBMED:7737196) ].

The human and mouse Xk-related (Xkr) families consist of nine and eight members, respectively, and mutations or variations in the gene of Xkr members are associated to human diseases. Xkr8 and other members of the family promote phosphatidylserine exposure in apoptotic cells [ (PUBMED:23845944) (PUBMED:25231987) ].

GO component:integral component of membrane (GO:0016021)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry XK-related