The domain within your query sequence starts at position 181 and ends at position 448; the E-value for the XendoU domain shown below is 1.4e-100.

KEELESISETIYRVDTNKAQKEDIVLNSQNRISPSETGNQVDRSPEPLFTYVNEKLFSKP
TYAAFINLLNNYQRATGHGEHFSAQQLEEQGVFLREVMKTAVMKELYSFLHHQNRYSSEQ
EFVDDLKNMWFGLYSRGNDEGDSSGFEHVFSGEVKKGKVTGFHNWIRFYLQEKEGLLDYY
SHNYDGPWDSYPDVLAMQFNWDGYYKEVGSVFIGSSPEFEFALYSLCFITRPGKKCHLSL
GGYPLAIQTYTWDKTTYGNGKKYIATAY

XendoU

 XendoU
PFAM accession number:PF09412
Interpro abstract (IPR018998):

This entry represents the C-terminal domain of EndoU endoribonucleases. The founding member XendoU is a uridylate-specific, divalent cation-dependent enzyme that produces molecules with 2',3'-cyclic phosphate ends [ (PUBMED:15755742) (PUBMED:16895992) ]. The human Endou, known as PP11, has endoribonuclease activity with placental tissue specificity [ (PUBMED:18936097) (PUBMED:28610924) ].

GO function:endoribonuclease activity (GO:0004521)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry XendoU