SMART: Pfam domain YTH

The domain within your query sequence starts at position 350 and ends at position 488; the E-value for the YTH domain shown below is 3e-42.

ARFFLIKSNNHENVSLAKAKGVWSTLPVNEKKLNLAFRSARSVILIFSVRESGKFQGFAR
LSSESHHGGSPIHWVLPAGMSAKMLGGVFKIDWICRRELPFTKSAHLTNPWNEHKPVKIG
RDGQEIELECGTQLCLLFP

YTH

PFAM accession number:	PF04146
Interpro abstract (IPR007275):	The YTH (YT521-B homology) domain has been suggested to be an evolutionarily conserved m6A-dependent RNA binding domain [ (PUBMED:26318451) ]. Proteins containing this domain includes mammalian YTHD and YTDC proteins, Arabidopsis CPSF30 (At1g30460), budding yeast Pho92 and fission yeast Mmi1. In Saccharomyces cerevisiae, Pho92 is a posttranscriptional regulator that regulates Pho4 mRNA stability by binding to the 3'-UTR in a phosphate-dependent manner. Its YTH domain exhibits RNA-binding activity [ (PUBMED:24206186) ]. In Schizosaccharomyces pombe, Mmi1 has been identified as eliminating meiosis-specific mRNAs [ (PUBMED:16823445) ]. Rat YTHDC1 (also known as YT521-B) is an alternative splicing regulator that recognizes and binds N6-methyladenosine (m6A)-containing RNAs. The YTH domain of YT521-B is a RNA-binding domain with a very degenerate sequence-specificity [ (PUBMED:25389274) ].
GO function:	RNA binding (GO:0003723)

PFAM accession number:

PF04146

Interpro abstract (IPR007275):

The YTH (YT521-B homology) domain has been suggested to be an evolutionarily conserved m6A-dependent RNA binding domain [ (PUBMED:26318451) ]. Proteins containing this domain includes mammalian YTHD and YTDC proteins, Arabidopsis CPSF30 (At1g30460), budding yeast Pho92 and fission yeast Mmi1.

In Saccharomyces cerevisiae, Pho92 is a posttranscriptional regulator that regulates Pho4 mRNA stability by binding to the 3'-UTR in a phosphate-dependent manner. Its YTH domain exhibits RNA-binding activity [ (PUBMED:24206186) ]. In Schizosaccharomyces pombe, Mmi1 has been identified as eliminating meiosis-specific mRNAs [ (PUBMED:16823445) ].

Rat YTHDC1 (also known as YT521-B) is an alternative splicing regulator that recognizes and binds N6-methyladenosine (m6A)-containing RNAs. The YTH domain of YT521-B is a RNA-binding domain with a very degenerate sequence-specificity [ (PUBMED:25389274) ].

GO function:

RNA binding (GO:0003723)

This is a PFAM domain. For full annotation and more information, please see the PFAM entry YTH