SMART: Pfam domain tRNA-synt

The domain within your query sequence starts at position 975 and ends at position 1302; the E-value for the tRNA-synt_His domain shown below is 3.8e-19.

GNFLIRTAKIQQLVCETIVRVFKRHGAVQLCTPLLLPRNRQIYEHNEAALFMDHSGMLVM
LPFDLRVPFARYVARNNILNLKRYCIERVFRPRKLDRFHPKELLECAFDIVTSTTNSSLP
TAETIYTIYEIIQEFPALQERNYSIYLNHTMLLKAILLHCGIPEDKLSQVYVILYDAVTE
KLTRREVEAKFCNLSLSSNSLCRLYKFIEQKGDLQDLTPTINSLIKQKTGVAQLVKYSLK
DLEDVVGLLKKLGVKLQVSINLGLVYKVQQHTGIIFQFLAFSKRRQRVVPEILAAGGRYD
LLIPKFRGPQTVGPVPTAVGVSIAIDKI

tRNA-synt_His

PFAM accession number:	PF13393
Interpro abstract (IPR041715):	HisRS is a homodimer and is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs [ (PUBMED:12269828) ]. This domain is also found at the C terminus of eukaryotic GCN2 protein kinase [ (PUBMED:7623840) ] and at the N terminus of the ATP phosphoribosyltransferase accessory subunit, HisZ. HisZ along with HisG catalyze the first reaction in histidine biosynthesis. HisZ is found only in a subset of bacteria and differs from HisRS in lacking a C-terminal anti-codon binding domain [ (PUBMED:10430882) ].

PFAM accession number:

PF13393

Interpro abstract (IPR041715):

HisRS is a homodimer and is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs [ (PUBMED:12269828) ]. This domain is also found at the C terminus of eukaryotic GCN2 protein kinase [ (PUBMED:7623840) ] and at the N terminus of the ATP phosphoribosyltransferase accessory subunit, HisZ. HisZ along with HisG catalyze the first reaction in histidine biosynthesis. HisZ is found only in a subset of bacteria and differs from HisRS in lacking a C-terminal anti-codon binding domain [ (PUBMED:10430882) ].

This is a PFAM domain. For full annotation and more information, please see the PFAM entry tRNA-synt_His