The domain within your query sequence starts at position 149 and ends at position 273; the E-value for the RPT_1 domain shown below is 1.71e-5.

RRGSPERFRPALPQLPVASASAATRTPTNRSLAPASPVRLSQPAPPISPVPVAQRAGQRS
ACCEPAHPDGTAGPGARRSDFLQKTGSNSFTVHPRGLPRSAVNRSLSNGPMTQESPTGPA
NGLSG

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.