The domain within your query sequence starts at position 181 and ends at position 242; the E-value for the RPT_1 domain shown below is 4.15e-8.

DWIEEKLQEVCEDLGITRDGHLNRKKLVSICEQYGLQNVDGAMLEEVFLSLDPDGTMSVE
DF

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.