The domain within your query sequence starts at position 181 and ends at position 291; the E-value for the RPT_1 domain shown below is 2.03e-5.

ISEPPVVVPDGPRSSESVEGSPFRPSHSSSAVFDEDKPIASSGTYNLDFDSIELVDNFQS
LEPCSADSKGQECKVSTRRKSTESVPPSKSTLSRSLSLQASDFDGASCPGS

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.