The domain within your query sequence starts at position 191 and ends at position 306; the E-value for the RPT_1 domain shown below is 1.99e-35.

VPKRRPQSQERGPMQLSADARDPEGAGGAGVLAAGKASGVDQRDTRRKAGPAWMVTRNEG
HEEKPLPPAQSQTQEGGPAAGKASGADQRDTRRKAGPAWMVTRSEGHEEKPLPPAQ

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.