The domain within your query sequence starts at position 203 and ends at position 297; the E-value for the RPT_1 domain shown below is 7.56e-6.

DLALMVAALAYNQWFTKLYCKDLRLGSEVLEQVLHTLSKSGSLEELVLDNAGLKTDFVQK
LAGVFGENGSCVLHALILSHNPIEDKGFLSLSQQL

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.