The domain within your query sequence starts at position 2320 and ends at position 2464; the E-value for the RPT_1 domain shown below is 3.97e-6.

SSSRMAPALSGANLTSPRVPLSAYDRVSGRTSPLMLDRARSRTPPSAPSQSRMTSERERA
PSPASRMVQASSQSLLPPAQDRPRSPVPSAFSDQSRSVVQTTPVAGSQSLSSGTVAKSTS
SASDHNGMLSGPAPGISHAEGGEPP

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.