The domain within your query sequence starts at position 250 and ends at position 352; the E-value for the RPT_1 domain shown below is 2.42e-20.

GKLAENKDLPQQQRDQELSSDSTTEPETATQLTSQQRSRRVSLTGQGQGKGPRKTSASKQ
GASRGSVAEQGSRRSSGVNQTQQRGSVAEQGSRRSSAVEQTQQ

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.