The domain within your query sequence starts at position 354 and ends at position 452; the E-value for the RPT_1 domain shown below is 2.42e-20.

GSVAEQGSRRSSTVEQTRQRGSVAEQGSRRSSTVEQTQRRGSVAEQGSRRSSGVNQTQQR
GSVAEQGSRRSSAVEQTQQRGSVAEQGSRRSSAMEQEPQ

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.