The domain within your query sequence starts at position 357 and ends at position 447; the E-value for the RPT_1 domain shown below is 1.03e-15.

PHTSAFLKAWVYRPGEDTEEENSDLDSAEEDTAQTGATPHTSAFLKAWVYRPGEDTEEEN
SDLDSAEEDTAQTGATPHTSPFLKAWVYRPG

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.