The domain within your query sequence starts at position 373 and ends at position 456; the E-value for the RPT_1 domain shown below is 1.04e-5.

VAKMPLRRPKMKKTPEKLDNTPASPPRSPTEPSDTPIAKGTYTFDIDKWDDPNFNPFSST
SKMQESPKLSQQSYNFDPDACEES

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.