The domain within your query sequence starts at position 397 and ends at position 620; the E-value for the RPT_1 domain shown below is 6.06e-9.

VLHKCVRVWLRYVHKRQWQQLLRARADGHFQQRALPAAFYTWYRGWLWHQQRRILHTKAV
RFHRGTLEKQVFALWRQKMSQHRENCLAERMAILQAEQQLLRRFWFVWHQQAAVCQLERQ
QQAMAIAHHHSGLLRRAFCIWKESTQGFRIERMGRAQAAHFHSAQLLSRAWSMWRECLAL
RLEEQQKLKCAALHSQCILLRRALQKWLVYQNRVRSVLREVAAR

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.