The domain within your query sequence starts at position 437 and ends at position 595; the E-value for the RPT_1 domain shown below is 1.57e-9.

EVSLLSLGTLSPAVVSFGTVATPADRLALMGGLEGFLGKMTEHGLQPDIKTLTLLAEVVE
PGSTAESSLLSVLDRHRVEADVTFFNTLIRKKSKLGDLEGAKALLPILAKKGIVPNLRTF
CNLAIGCHRPRDGMQLLADMKKSQVSPNIHIYSTLINAA

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.