The domain within your query sequence starts at position 450 and ends at position 597; the E-value for the RPT_1 domain shown below is 3.31e-5.

PTVNQTQQQMGPRPPQNNPLSQGFQQPVSSPGRNPMVQQGNVPPNFMVMQQQPPNQGPQS
LHPGLGGMPKRLPPGFSAGQANPNFMQGQVPSTTAATPGNSGALQLQANQNVQHAGGQGA
GPPQNQMQVSHGPPNMMQPSLMGIHGNI

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.