The domain within your query sequence starts at position 1452 and ends at position 1660; the E-value for the RPT_2 domain shown below is 3.41e-11.

FDRFEGKLSPLWYKITGGQVGTGCGTLNDGRSLYFNGLGKREARTVPLDTRNIRLVQFYI
QIGSKTSGITCIKPRARNEGLVVQYSNDNGILWHLLRELDFMSFLEPQIISIDLPREAKT
PATAFRWWQPQHGKHSAQWALDDVLIGVNDSSQTGFQDKFDGSIDLQANWYRIQGGQVDI
DCLSMDTALIFTENIGKPRYAETWDFHVS

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.