The domain within your query sequence starts at position 2038 and ends at position 2138; the E-value for the RPT_2 domain shown below is 8.58e-5.

REGNPKSRGEREAASEPKRDRRDPSTDKNGPDTFPVEVLERKPPEKTYKSKRGRARSTRS
AMDRAAHQRSLEMAARAAGQAADKEAGPAAASPQESESPQK

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.