The domain within your query sequence starts at position 2156 and ends at position 2212; the E-value for the RPT_2 domain shown below is 3.95e-6.

PRFRFGPPEDMPQTSSSHSDLGQLASQGGLGMYETPLFLAHEEESGGRSVPTTPLQV

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.