The domain within your query sequence starts at position 277 and ends at position 414; the E-value for the RPT_2 domain shown below is 9.67e-8.

DTKSCAQSQAVAIIQNDDMAGAEADKEDLKNMSKAGSGIDMKVPGQPHIAANNLAEAVPG
AKNDAWDNAKDICEAEADIRTCLIQSETVAKIETEATSSATMDGGKDANAKAMTDVNVTD
TQPQAVTSDQTEAMPDAK

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.