The domain within your query sequence starts at position 293 and ends at position 375; the E-value for the RPT_2 domain shown below is 1.36e-5.

QWIRHHTAAFEERKFPSSFEEIEILWCQFLKFKETELPAKEADKNRSKVIYQSLEGAVQA
GQLKIPPGYHPLDVEKEWGKLHV

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.