The domain within your query sequence starts at position 391 and ends at position 477; the E-value for the RPT_2 domain shown below is 3.13e-7.

DYCRRLRDAKLHSSSLQFTLHCALQANRTALAKAVMEALREEGFPIRPHYFWPLLAGHQK
TKNVQGIIDILKIMNKVGVDPDQETYI

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.