The domain within your query sequence starts at position 451 and ends at position 506; the E-value for the RPT_2 domain shown below is 5.92e-5.

QVLIRAPTLTPSGQISWQTVQVQNIQSLSNLQVQNAGLSQQLTITPVSSSGGTTLA

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.