The domain within your query sequence starts at position 442 and ends at position 586; the E-value for the RPT_3 domain shown below is 9.64e-5.

DTTHLSQVAIPTEKPVPNSEEKWKARVDEIEDAIYVTMEILSNWGNASWVGLTEVQFFDL
NNIKLYVSPHDVDIRNAVLPGELGCLVNRDLVSKKDPPVWTCPFHPPLQLYFIIHNMRQL
RDFGLTMIKVRNYWTADGDLDIGAK

This is a significant internal repeat in the query protein sequence, as detected by the Prospero program.